“泽泻乙醇提取物相当于生药100 g/ kg 给小鼠灌胃,3 d 后未见死亡。泽泻浸膏粉1 g 及2 g/ kg (相当于临床剂量20 及40倍)混于饲料中喂饲大鼠3 个月,发育未见异常,但病理切片显示肝细胞及肾近曲小管有不同程度的浊肿与变性,且大剂量组较小剂量组明显,给药组较对照组明显[21] 。泽泻甲醇提取物给小鼠静脉注射或腹腔注射的LD50分别为0.78 和1.27 g/ kg ,口服4 g/kg 无死亡[22] 。” (1374页)。
“There were 11 different herbal elements in the drug formula. One of the elements, Zexie listed in Table 1, has been reported to have hepatotoxicity on liver and other organs in studies with mice in the Chinese literature. ”(药方含有11种中药材,其中之一是泽泻。据中文文献报道,泽泻在小鼠的试验中具有肝毒性。)
Jiang ZY et al. A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis. Planta Med. 2006 Aug;72:951-954.
Jiang ZY et al. Two new sesquiterpenes from Alisma orientalis. Chem Pharm Bull (Tokyo). 2007 Jun;55:905-907.
真相五:英文资料显示,泽泻具有保肝功能:
Hong X et al. Protective effects of the Alisma orientalis extract on the experimental nonalcoholic fatty liver disease. J Pharm Pharmacol. 2006 Oct;58:1391-1398.